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Meet The Team

Eczema (Atopic Dermatitis):

Modern Understanding

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A. What’s happening in the skin

  • Impaired skin barrier

  • Increased transepidermal water loss (TEWL)

  • Dryness and micro‑cracks

  • Reduced ceramides

  • Hyper‑reactive immune response

  • Increased susceptibility to irritation

 

B. Microbiome changes

  • Reduced microbial diversity

  • Overgrowth of Staphylococcus aureus

  • Fewer protective commensals

 

C. What this leads to

  • Dryness

  • Redness

  • Itching

  • Sensitivity

  • Recurrent flares

 

D. Modern management approach

  • Barrier‑supportive care

  • Gentle, long‑term maintenance

  • Microbiome‑aware formulations

  • Steroid‑sparing strategies

Understanding dermatological conditions

Seborrheic Dermatitis:

Modern Understanding

A. What’s happening in the scalp/skin

  • Barrier disruption in sebum‑rich areas

  • Increased oil + altered lipid composition

  • Local inflammation

  • Flaking and scaling

 

B. Microbiome changes

  • Increased Malassezia activity

  • Secondary bacterial amplification

  • Reduced microbial balance

 

C. What this leads to

  • Flaking

  • Redness

  • Itching

  • Recurrent flares on face, scalp margins, ears, chest

 

D. Modern management approach

  • Antifungal “reset” during flares

  • Leave‑on maintenance between flares

  • Barrier‑supportive, microbiome‑aware care

  • Gentle, long‑term use on sensitive areas

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Considerations in Long-Term Management

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Chronic inflammatory skin conditions such as atopic dermatitis and seborrheic dermatitis typically require a combination of flare control and long-term maintenance.

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Topical corticosteroids and other prescription therapies play a well-established and clinically important role in managing acute flares. However, long-term or repeated reliance on flare-directed therapies alone can present practical and physiological considerations that influence ongoing skin health and disease recurrence.

 

Role of Topical Corticosteroids in Flare Management

 

  • Rapid and effective reduction of inflammation, redness, and itching

  • Cornerstone of flare management in both pediatric and adult patients

  • Clinically essential and widely supported by dermatology guidelines for short-term use

 

Considerations with Long-Term or Repeated Use

 

  • Not intended for continuous, long-term daily application, particularly on sensitive or thin skin areas

  • Prolonged or frequent use may impact skin barrier integrity over time

  • Discontinuation after repeated use may be associated with rebound flares in some patients

  • Does not directly address underlying barrier dysfunction or microbiome imbalance that contribute to recurrence

 

The Maintenance Gap

 

While topical corticosteroids are effective for controlling inflammation during flares, many patients experience cycles of improvement followed by recurrence once treatment is tapered or discontinued. This highlights a recognized need for supportive, non-steroidal maintenance strategies that focus on barrier strength, skin comfort, and microbial balance between flares.

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Blossom Microbiotics focuses on dermocosmetic formulations designed to support symptom relief and skin stability in mild to moderate inflammatory skin conditions, particularly as part of supportive maintenance between flares
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Selected Reads

Atopic Dermatitis 

  • Weidinger S, Novak N. (2016). Atopic dermatitis. Lancet.

  • Nakatsuji T et al. (2017). Antimicrobials from commensal bacteria protect against Staphylococcus aureus. Science Translational Medicine.

  • Kobayashi T et al. (2015). Dysbiosis and barrier dysfunction in atopic dermatitis. Journal of Allergy and Clinical Immunology.

  • Irvine AD, McLean WHI, Leung DYM. (2011). Filaggrin mutations and atopic dermatitis. New England Journal of Medicine.

 

Seborrheic Dermatitis

  • Dessinioti C, Katsambas A. (2013). Seborrheic dermatitis: etiology, risk factors, and treatments. Journal of the European Academy of Dermatology and Venereology.

  • Clarke J, Nelson AM. (2019). Seborrheic dermatitis and dandruff: a comprehensive review. Journal of Clinical and Aesthetic Dermatology.

  • Gaitanis G et al. (2012). Malassezia species and seborrheic dermatitis. Clinical Microbiology Reviews.

  • Ro BI, Dawson TL. (2005). The role of Malassezia in scalp disorders. Journal of Investigative Dermatology Symposium Proceedings.

© Blossom Microbiotics LLC. All rights reserved.
A North Carolina, U.S. based dermocosmetic biotechnology company.
These formulations are dermocosmetic products and are not intended to diagnose, treat, cure, or prevent any disease
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                        More to come. Stay tuned. 
   
                             info@blossommicrobiotics.com

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